Mano Joseph - Efrei Paris


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Mano Joseph MATHEW Responsable de la majeure Bio-informatique



Mano Joseph MATHEW in charge of the major Bioinformatics and Coordinator of biological studies cycle L in May 2019, specialising in Epigenomics and Bioinformatics. He has a Master degree in Bioinformatics from Manipal University (2008) and Bachelor degree in Biotechnology from Sardar Patel University (2006). He completed his PhD (Microbiology and infectious diseases) in 2013 from Aix-Marseille Université with mention très honorable and funding from APHM & World Health Organization (WHO). This was followed by a two-year (2013-2015) Post-doctoral fellowship at Centre d’immunologie de Marseille-Luminy (CIML), Marseille, France, with the Prof. Pierre Ferrier team where he investigated the molecular mechanisms involved in the control of differentiation events during lymphocyte development, including antigen receptor gene expression and recombination. Here he deciphered functional activity of TLX homeodomain oncogenes in T-cell acute lymphoblastic leukaemia (T-ALL) using molecular biology approaches and especially, high-throughput genomics Chip-Seq, RNA-Seq and ExomeSeq data.

Later on, he did a second Post-doctoral (2016-2018) fellowship at Centre de Recherche des Cordeliers (CRC), Paris, France with Prof. Nicolas Venteclef team, using multiomics data analysis / integration techniques. His research attempted to better understand how alterations of the epigenome control metaflammation, i.e. inflammation in the context of metabolic diseases such as obesity, type 2 diabetes, fatty liver disease and atherosclerosis.


  • Epigenomic reprogramming in Cancer
  • System’s Biology and Multiomics Data Integration
  • AI powered healthcare